Name: Kashifa Khanum
email:
kashifakhanum@hotmail.com
qualification: B.Pharm
matter: Chemical composition / key active
constituents : Amla is highly nutritious and is an important
dietary source of Vitamin C, minerals and amino acids. The
edible fruit tissue contains protein concentration 3-fold
and ascorbic acid concentration 160-fold compared to that of
the apple. The fruit also contains considerably higher
concentration of most minerals and amino acids than apples.
Glutamic acid, proline, aspartic acid, alanine, and lysine
are 29.6%, 14.6%, 8.1%, 5.4% and 5.3% respectively of the
total amino acids. The pulpy portion of fruit, dried and
freed from the nuts contains: gallic acid 1.32%, tannin,
sugar 36.10%; gum 13.75%; albumin 13.08%; crude cellulose
17.08%; mineral matter 4.12% and moisture 3.83%. Amla fruit
ash contains chromium, 2.5 ppm; zinc 4 ppm; and copper, 3
ppm.Key Active ConstituentsEmblicanin A&B, Puniglucanin,
Pedunculagin, 2-keto-gluconolactone (Vitamin-C equivalents).
Ellagic acid, Hexahydroxy-diphenic acid and conjugates.
Pharmacology:
Emblica officinalis is effective in the treatment of
amlapitta [peptic ulcer]and in dyspepsia. The fruits exhibit
hypolipiadaemic and antiatherosclerotic effects in rabbits &
rats. The fruit extract has antimutagenic activity on
certain directly acting mutagens in some strains of
Salmonella typhimurium.The extract of amla also has
antimicrobial properties. Amlaki is an antioxidant with free
radical scavenging properties which may be due to the
presence of high levels of super oxide dismutase.
References:
CAS, IP, Ayurveda book etc.
1 Chem Abstr, 1992 [116- 19982, 127273]; 1993 [119-103470];
1989[110-73906];
Vohora, Indian Drugs, [1989-26(10), 526]; Janjua, Hamdard,
1991 [34(2)-104];
Yaqeenudin et. al., Pakist J Sci Ind Res, 1990 [33-268].
2 Roy, A.K. et. al., Int. J.of Pharmacog., 1991, v. 29(2),
117-126.
3 Mand, J.K. et. al., J. Res. Edu. in Ind.Med., 1991, v.,
10(2), 1-7.
4 Ghosh, A. et. al., Int. J. of Pharmacog., 1993, v. 31(2),
116-120.
5 Mathur, R. et. al., J. of Ethnopharmacol., 1996, v.,
50(2), 61-68.
6 Singh, B.N. and Sharma, P.V., J.Res. Ind. Med., 1971, 5,
223.
7 Ramaswamy, Minor Forest Products, Mysore, 1945,55;
Damodaran & Nair,Biochem.J. 1936,30,1014;Giri,Indian J. med.
Res., 1939, 27, 429; Mitra & Ghosh,Ann. biochem.1941, 1,
307; Srinivasan, loc. cit.
8 Chawla et. al., 1982, Indian J. Med. Res. 76 (Suppl.),
95-98.
Occupation: Pharmaceutical Industry
City: Karachi
Country: Pakistan
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